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ORIGINAL ARTICLE
Year : 2017  |  Volume : 3  |  Issue : 2  |  Page : 9-13

To Evaluate the In Vitro Transcorneal Penetration of Ofloxaxcin, Pefloxacin, Lomefloxacin and Sparfloxacin in The Presence and Absence of Amniotic Membrane Using Goat Cornea


1 Department of Ocular Pharmacology and Pharmacy, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi-110029, India
2 Department of Pharmacology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi-110029, India
3 Department of Medical Ophthalmology, Retina and Uvea, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi-110029, India
4 Department of Pediatric Ophthalmology and Oculoplasty, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi-110029, India

Correspondence Address:
Nihar Ranjan Biswas
Director & Vice-Chancellor, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna-800014, Bihar; Department of Pharmacology, All India Institute of Medical Sciences, New Delhi-110029; Director & Vice-Chancellor, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna-800014, Bihar
India
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Source of Support: None, Conflict of Interest: None


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This study was intended to evaluate the in vitro transcorneal penetration of ofloxaxcin, pefloxacin, lomefloxacin and sparfloxacin in the presence and absence of amniotic membrane using goat cornea. This was an experimental study to estimate transcorneal penetration of four 0.3% fluoroquinolone formulations. In the absence of amniotic membrane, the calculated flux of the transfer in case of ofloxaxcin, pefloxacin, lomefloxacin and sparfloxacin 0.3% were found to be 2.41μg/cm2/hr, 4.45 μg/cm2/hr, 7.4 μg/cm2/hr and 0.968 μg/cm2/hr respectively. In the presence of amniotic membrane these values changed to 3.38 μg/cm2/hr, 2.15μg/cm2/hr, 5.75 μg/cm2/hr and 2.4 μg/cm2/hr respectively. The transcorneal permeation studies using goat cornea showed the cumulative release in the following order as lomefloxacin>pefloxacin>ofloxacin>sparfloxacin


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