To evaluate and quantify the Rifampicin Sensitive/Resistant tuberculosis using Xpert MTB/RIF Assay : Our Experience at the DOTS plus site

Manish Shankar; Satyadeo Choubey; Saket Sharma; Rakesh Kumar; Shishir Kumar

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ORIGINAL ARTICLE

Year : 2019 \| Volume : 5 \| Issue : 2 \| Page : 118-125

To evaluate and quantify the Rifampicin Sensitive/Resistant tuberculosis using Xpert MTB/RIF Assay : Our Experience at the DOTS plus site Manish Shankar¹, Satyadeo Choubey², Saket Sharma³, Rakesh Kumar⁴, Shishir Kumar⁵ ¹ Additional Professor, Dept. of TB & Chest, IGIMS, Patna, Bihar, India ² Associate Professor, Dept. of TB & Chest, IGIMS, Patna, Bihar, India ³ Assistant Professor, Dept. of Pneumnology, IGIMS, Patna, Bihar, India ⁴ Associate Professor, Dept. of Microbiology, IGIMS, Patna, Bihar, India ⁵ Associate Professor, Dept. of Community Medicine, IGIMS, Patna, Bihar, India Correspondence Address: Satyadeo Choubey Associate Professor, Dept. of TB & Chest IGIMS India Source of Support: None, Conflict of Interest: None

Context: Cartridge based nucleic acid amplification test (CBNAAT) is a diagnostic tool which detects both Mycobacterium tuberculosis and its resistance to Rifampicin. Bihar has a high burden of tuberculosis but the data regarding the total and multidrug resistant TB (MDR-TB) burden is lacking. Aims: To quantify the burden of TB and Rifampicin resistance presenting in a DOTS plus site hospital of Bihar using CBNAAT. Setfngs and Design: A hospital based cross sectional study. Methods and Material: All the suspected patients coming to the department of TB & chest at our institute were made to deposit there site specific samples for CBNAAT. The test result (detected/not detected, Rifampicin sensitive/ resistant) were fed into Microsoft Excel and analysis was done using Epi-info statistical software. Statistical analysis used: Descriptive statistic was used. Results: Out of 4096 suspected patients, 958 were positive by CBNAAT between February 2016 to November 2017. 772 cases (80.58%) were sensitive while 186 (19.41%) were resistant to Rifampicin. It was pulmonary TB in 710 patients and extra pulmonary TB (EPTB) in 248 patients. Among males, 539 (20.4%) were sensitive while 124(4.7%) were resistant to Rifampicin and 233 (16.1%) and 62 (4.3%) respectively in females. 16-35 age group had the highest TB burden. Patna district has the highest TB burden. Conclusions: Bihar harbors a significant burden of TB patients including the drug resistant cases. Utmost attention of TB control programme and prompt treatment is need of the hour.



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