Assessment of serum Vitamin D level in patient of mild to moderate asthma

Sunita; Rekha Kumari; Ashok Sharan; Manish Shankar

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ORIGINAL ARTICLE

Year : 2019 \| Volume : 5 \| Issue : 2 \| Page : 135-138

Assessment of serum Vitamin D level in patient of mild to moderate asthma Sunita¹, Rekha Kumari², Ashok Sharan³, Manish Shankar⁴ ¹ Associate professor, Dept. of Physiology, IGIMS, Patna, Bihar, India ² Additional professor & HOD, Dept. of Biochemistry, IGIMS, Patna, Bihar, India ³ Professor & HOD, Dept. of Physiology, IGIMS, Patna, Bihar, India ⁴ Additional Professor, Dept. of TB & chest, IGIMS, Patna, Bihar, India Correspondence Address: Rekha Kumari Additional professor & HOD, Dept. of Biochemistry, IGIMS, Patna, Bihar India Source of Support: None, Conflict of Interest: None

Background: Asthma is one of the most common chronic disease affecting millions of population worldwide. It is a chronic respiratory disease characterized by increased airway inflammation and hyper-responsiveness. Several studies shows that deficiency of Vitamin D (25-OH) is related to occurrence of pulmonary diseases as well as reduced lung function and increased airway inflammation leading to poor results in asthmatic patients. In context to India, there were fewer studies which have evaluated the relationship between vitamin D (25- OH) and pulmonary function and its role in asthma. Thus, the present study was undertaken to study the role of vitamin D deficiency or insufficiency in mild to moderate asthmatic patients. Aims: To assess the serum vitamin D(25-OH) level in mild to moderate asthmatic patients. Material & Methods: The present study included 100 subjects of either sex with age group of 15 - 40 years. They were divided into two groups. Group A (control) include 40 healthy individual, and Group B include 60 asthmatic patients based upon GINA guidelines. Pulmonary function test and Vitamin D analysis were performed in both the groups. Results: The study showed that serum vitamin D level was significantly decreased in asthmatic patients when compared with the control group (p<0.01). Conclusion: Vitamin D deficiency is relatively frequent in asthmatic patients and there is a significant inverse relationship between serum vitamin D and severity of asthma symptoms. Therefore, measuring serum levels of vitamin D should be considered in the routine assessment of asthmatic patients. It may serve as a marker of asthma severity.



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