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Year : 2021  |  Volume : 7  |  Issue : 1  |  Page : 39-42

Relation of glycated hemoglobin with nerve conduction study and proprioception in patients with type 2 diabetes mellitus

1 Department of Physiology, IGIMS, Patna, Bihar, India
2 Department of Neurology, IGIMS, Patna, Bihar, India

Correspondence Address:
Josni Khah
Department of Physiology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jigims.jigims_16_21

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Background and Aim: Diabetic peripheral neuropathy is a major complication of type 2 diabetes mellitus (T2DM). Association of elevated glycated hemoglobin (HbA1c) and nerve function is known, but its relationship with proprioception is still unknown. This study was conducted to find the correlation of HbA1c with nerve conduction study (NCS) and proprioception in T2DM patients. Materials and Methods: 88 patients of T2DM of <5 years duration, between the age group 30 and 60 years, participated in the study. NCS of tibial motor, peroneal motor, and sural sensory nerves was done. Proprioception was assessed by testing the absolute error scores of knee joint position sense (JPS) with a digital inclinometer. Pearson correlation coefficient was used to analyze the relation of HbA1c with NCS parameters and the knee JPS errors. Results: HbA1c showed a positive correlation with distal latency and a negative correlation with amplitude and conduction velocity. JPS errors showed a moderate positive correlation with HbA1c. Conclusion: HbA1c values have a significant relation with the development of peripheral neuropathy in T2DM patients. This effect was observed on both nerve conduction studies as well as on proprioception test.

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